Endocrine Disruption and Reproductive Pathology
نویسندگان
چکیده
منابع مشابه
Endocrine disruption of oestrogen action and female reproductive tract cancers.
Endocrine disrupting chemicals (EDC) are ubiquitous and persistent compounds that have the capacity to interfere with normal endocrine homoeostasis. The female reproductive tract is exquisitely sensitive to the action of sex steroids, and oestrogens play a key role in normal reproductive function. Malignancies of the female reproductive tract are the fourth most common cancer in women, with end...
متن کاملEndocrine Disruption and Human Reproductive Effects: An Overview
Humans of all ages interact with their environment on a daily basis and are thus exposed to a variety of both man-made and naturally occurring chemicals through the air they breath, the water they drink and the food they eat. The potential for exposure to environmental contaminants to impact the function of the reproductive system and affect normal development of the reproductive tract has beco...
متن کاملQSAR models for reproductive toxicity and endocrine disruption activity.
Reproductive toxicity is an important regulatory endpoint, which is required in registration procedures of chemicals used for different purposes (for example pesticides). The in vivo tests are expensive, time consuming and require large numbers of animals, which must be sacrificed. Therefore an effort is ongoing to develop alternative In vitro and in silico methods to evaluate reproductive toxi...
متن کاملImmune-Endocrine Cross-Talk in Reproductive Biology and Pathology
1 Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research of PAS, 10-748 Olsztyn, Poland 2Department of Morphology and Function, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal 3 Laboratory of Reproductive Immunology, Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of PAS, 53-114...
متن کاملAre problems with male reproductive health caused by endocrine disruption?
More than 20 years ago, it was suggested that the normal reproductive development of the male embryo may be aVected by exposure to oestrogens, the focus initially being on the mother’s endogenous oestrogen. In 1993, Sharpe and Skakkebaek proposed the hypothesis that increased oestrogen exposure in early life increases the risk of the two genital malformations hypospadias and cryptorchidism, and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2019
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623319879903